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Estradiol (E2) on TRT

Why the assay and your symptoms matter before you act on E2.

Check the name of the assay

Standard immunoassay and sensitive LC-MS/MS are distinct methods. Mayo recommends mass spectrometry for low estradiol concentrations in men. Check the method on your report before comparing with older draws.

Put the result in context

Mayo lists 10 to 40 pg/mL for adult men on its serum estradiol assay. Use the range on your own report. A single E2 value does not establish the cause of symptoms or a reason to change treatment. Bring persistent symptoms or unexpected changes to your prescriber.

Sources

Bring the right question to your next draw.

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