TRT04 / BENCHMARKS
Put the number in context.
A reference interval describes what a lab or study observed in a defined population. A clinical threshold can guide when to follow up.
Reference intervals & action thresholds
| Marker | Number & type | Where it applies |
|---|---|---|
| Total testosterone | 264 to 916 ng/dL Research reference interval | Healthy nonobese men aged 19 to 39, harmonized across U.S. and European cohorts. Use your performing lab’s interval. Harmonized testosterone reference interval, Travison et al. (2017) → |
| Estradiol (E2) | 10 to 40 pg/mL Lab-specific reference interval | Mayo adult male serum estradiol example. Check assay and your report’s own interval. Mayo Clinic Laboratories, serum estradiol test catalog → |
| Hematocrit | Above 54% Clinical action threshold | Endocrine Society threshold for intervention during prescribed TRT. Contact your prescriber promptly at 54% or higher. Endocrine Society clinical practice guideline, Bhasin et al. (2018) → |
| PSA | Rise >1.4 ng/mL or confirmed PSA >4 ng/mL Clinical referral threshold | Endocrine Society criteria for urology consultation in the first year of TRT for patients undergoing prostate monitoring. Endocrine Society clinical practice guideline, Bhasin et al. (2018) → |
Use the range and units on your report. Discuss unexpected changes or abnormal values with a clinician.